Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention

ND Volkow, C Blanco - World Psychiatry, 2023 - Wiley Online Library
Substance use disorders (SUDs) are highly prevalent and exact a large toll on individuals'
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …

Biopharmaceuticals against substance use disorders–Present and future

T Vavilis, E Stamoula, A Sachinidis… - European Journal of …, 2023 - Elsevier
Background and objectives Pharmacological treatments available for substance use
disorder (SUD) focus on pharmacodynamics, agonizing or antagonizing the drug of abuse …

Early life adversity: Epigenetic regulation underlying drug addiction susceptibility

JJ Winter, KL Rodríguez-Acevedo, M Dittrich… - Molecular and Cellular …, 2023 - Elsevier
Drug addiction is a leading cause of disability worldwide, with more than 70,000 Americans
dying from drug overdose in 2019 alone. While only a small percentage of chronic drug …

[PDF][PDF] How life events may confer vulnerability to addiction: the role of epigenetics

SX Liu, AC Harris, JC Gewirtz - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
Substance use disorders (SUDs) impose severe burdens on individuals and society
(Sharma et al., 2019; Strang et al., 2020; Ignaszewski, 2021; Peterson et al., 2021). Despite …

Association between alcohol consumption and DNA methylation in blood: a systematic review of observational studies

D Dragic, SL Chang, K Ennour-Idrissi, F Durocher… - …, 2022 - Taylor & Francis
Aim: We systematically reviewed and evaluated current literature on alcohol consumption
and DNA methylation (DNAm) at the genome-wide and probe-wise level in blood of adults …

[PDF][PDF] Involvement of nucleic-acid methylation on biology and evolution: from first hominids to modern humans–Review

G Dorado, F Luque, FJ Esteban, P Pascual… - …, 2022 - researchgate.net
Recent developments in molecular biology, in general, and nucleic-acid sequencing, in
particular, have allowed fascinating discoveries. Thus, it is now known that DNA and RNA …

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

A Filošević Vujnović, I Stanković Matić… - Future …, 2024 - mdpi.com
Addiction is a complex brain disease influenced by genetic, environmental, and neurological
factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in …

Whole Genome DNA Methylation Profiling of D2 Medium Spiny Neurons in Mouse Nucleus Accumbens Using Two Independent Library Preparation Methods

Y Li, H Xu, JM Chitaman, J Feng - Genes, 2022 - mdpi.com
DNA methylation plays essential roles in various cellular processes. Next-generation
sequencing has enabled us to study the functional implication of DNA methylation across …

Effets inter-/transgénérationnels de la cocaïne: une revue de la littérature

F Noble - Bulletin de l'Académie Nationale de Médecine, 2024 - Elsevier
Résumé De plus en plus de personnes, en particulier celles en âge de procréer,
consomment des substances addictives, et de plus en plus de données suggèrent que la …

Introduction to Substance Use Among Older Adults

L Bessey, D Oseni, A Walaszek - Substance Use in Older Adults, 2024 - books.google.com
Clinicians are caring for more and more older adults (those 65 and older) with substance
use disorders (SUDs). The prevalence of SUDs—especially alcohol use disorder (AUD) and …