Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] Colon cancer and colorectal cancer: Prevention and treatment by potential natural products
Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …
Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond
YK Abd El Fattah, AI Abulsoud, SG AbdelHamid… - International Journal of …, 2022 - Elsevier
Long non-coding RNAs (lncRNAs) were, once, viewed as “noise” for transcription. Recently,
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …
[HTML][HTML] Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
Therapeutic targeting of the IGF axis
E Osher, VM Macaulay - Cells, 2019 - mdpi.com
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …
development, and when deregulated makes an important contribution to disease. Here, we …
NF-κB pathways in the development and progression of colorectal cancer
Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …
[HTML][HTML] Natural products for treating colorectal cancer: A mechanistic review
X Huang, Z Yang, Q Xie, Z Zhang, H Zhang… - Biomedicine & …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancers in humans and is
closely linked to the global cancer-related mortalities worldwide. Molecular pathological …
closely linked to the global cancer-related mortalities worldwide. Molecular pathological …
Antioxidant and anticancer activities of chamomile (Matricaria recutita L.)
Objectives The present study aimed at determining the antioxidant activity, total phenols and
flavonoids and to evaluate the antiproliferative activity of ethanolic extract of Matricaria …
flavonoids and to evaluate the antiproliferative activity of ethanolic extract of Matricaria …
RAS-mediated oncogenic signaling pathways in human malignancies
Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …
functioning of major signaling pathways involved in the initiation and development of human …