Preclinical anticancer studies on the ethyl acetate leaf extracts of Datura stramonium and Datura inoxia

B Nasir, MW Baig, M Majid, SM Ali, MZI Khan… - … medicine and therapies, 2020 - Springer
Background Cancer is a horrific disease relentlessly affecting human population round the
globe. Genus Datura encompasses numerous species with reported medicinal uses …

Shedding light on the dark genome: Insights into the genetic, CRISPR-based, and pharmacological dependencies of human cancers and disease aggressiveness

D Kafita, P Nkhoma, K Dzobo, M Sinkala - Plos one, 2023 - journals.plos.org
Investigating the human genome is vital for identifying risk factors and devising effective
therapies to combat genetic disorders and cancer. Despite the extensive knowledge of the" …

In Vitro Antiproliferative Effects and Phytochemical Characterization of Carissa edulis ((Forssk) Vahl) and Pappea capensis (Eckyl and Zeyh) Extracts

CW Muruthi, MP Ngugi, SM Runo… - Journal of Evidence …, 2023 - journals.sagepub.com
Cancer mortality is a global concern. The current therapeutic approaches despite showing
efficacy are characterized by several limitations. Search for alternatives has led to the use of …

Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization

Y Shan, Z Wei, L Tao, S Wang, F Zhang, C Shen… - Scientific reports, 2016 - nature.com
Cancer prevention through intake of biologically active natural products appears to be an
accessible way to reduce the risk of cancer. Diallyl disulfide (DADS), a major garlic …

Circular RNAs in cancer and diabetes

A Hatibaruah, M Rahman, S Agarwala, SA Singh… - Journal of genetics, 2021 - Springer
Circular RNAs (circRNAs) are a class of noncoding RNA molecules formed by the back
splicing process. Compared to linear mRNA molecules they are more stable. CircRNA acts …

A photoactivatable chemotherapeutic Ru (II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi …

MG Elias, S Mehanna, E Elias, RS Khnayzer… - Chemico-Biological …, 2021 - Elsevier
Photoactivated chemotherapy (PACT) is an emerging strategy for targeted cancer therapy.
Strained Ru complexes with pseudo-octahedral geometry may undergo photo-induced …

Research progress on traditional Chinese medicine-induced apoptosis signaling pathways in ovarian cancer cells

Y Wang, L Xie, F Liu, D Ding, W Wei, F Han - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance As a" silent killer" that threatens women's lives and health,
ovarian cancer (OC) has the clinical characteristics of being difficult to detect, difficult to treat …

Epigenetics reactivation of Nrf2 in prostate TRAMP C1 cells by curcumin analogue FN1

W Li, D Pung, ZY Su, Y Guo, C Zhang… - Chemical research in …, 2016 - ACS Publications
It has previously been shown that curcumin can effectively inhibit prostate cancer
proliferation and progression in TRAMP mice, potentially acting through the hypomethylation …

Effect and mechanism of tanshinone I on the radiosensitivity of lung cancer cells

Y Yan, W Su, S Zeng, L Qian, X Chen, J Wei… - Molecular …, 2018 - ACS Publications
Background: Resistance to radiotherapy is one of the main obstacles to improving cancer
prognoses. To effectively destroy cancer cells, novel radiation sensitizers are needed …

Chromatin and cancer: implications of disrupted chromatin organization in tumorigenesis and its diversification

P Sehgal, P Chaturvedi - Cancers, 2023 - mdpi.com
Simple Summary Human DNA is~ 2 m long, but is efficiently packaged in cell nucleus that is
a million times smaller. The concerted action of several enzymes enables this packaging …