Glioma is one of the most perplexing cancers because of its infiltrating nature, molecular
signaling, and location in central nervous system. Blood–brain barrier acts as a natural …

Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with
different tissue-specific functions. ERα and ERβ are two nuclear members of this family …

Background Natural bioproducts are invaluable resources in drug discovery. Isoquinoline
alkaloids of Chelidonium majus constitute a structurally diverse family of natural products …

Melanoma is the most common type of skin cancer. Signal transducer and activator of
transcription 3 (STAT3) signaling has been demonstrated to be a therapeutic target for …

GDF15 plays a paradoxical role during carcinogenesis; it inhibits tumour growth in the early
stages and promotes tumour cell proliferation in the late stages of cancer. Besides, GDF15 …

Resembling the development of cancer by multistep carcinogenesis, the evolution towards
metastasis involves several passages, from local invasion and intravasation, encompassing …

Since the Hedgehog signaling pathway has been associated with cancer, it has emerged as
a therapeutic target for cancer therapy. The main target among the key Hedgehog proteins is …

Background Resveratrol has demonstrated many beneficial effects against cancers;
however, the mechanism remains unclear. Non–small cell lung cancer accounts for 80% of …

Hepatocellular carcinoma (HCC) is the commonest primary malignancy with poor patient
prognosis and a high mortality rate. In this study, phytochemicals characterized from …

Cancer, a formidable disease with a significant mortality rate, continues to claim the lives of
thousands of individuals annually in contemporary society. Conventional cancer therapies …