Antimicrobial host defence peptides: functions and clinical potential
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …
occurring peptides that can combat infections through their direct microbicidal properties …
Mechanisms of action for antimicrobial peptides with antibacterial and antibiofilm functions
N Raheem, SK Straus - Frontiers in microbiology, 2019 - frontiersin.org
The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial
peptides (AMPs). Recent work has shown that these molecules have great potential not only …
peptides (AMPs). Recent work has shown that these molecules have great potential not only …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
The immunology of host defence peptides: beyond antimicrobial activity
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
Microtiter plate assays to assess antibiofilm activity against bacteria
Bacterial biofilms demonstrate high broad-spectrum adaptive antibiotic resistance and
cause two thirds of all infections, but there is a lack of approved antibiofilm agents. Unlike …
cause two thirds of all infections, but there is a lack of approved antibiofilm agents. Unlike …
Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface.
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …
Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?
MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
[HTML][HTML] Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria
G Batoni, G Maisetta, S Esin - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Biofilm-associated infections represent one of the major threats of modern medicine. Biofilm-
forming bacteria are encased in a complex mixture of extracellular polymeric substances …
forming bacteria are encased in a complex mixture of extracellular polymeric substances …
Antimicrobial peptides: an introduction
EF Haney, SC Mansour, REW Hancock - Antimicrobial peptides: methods …, 2017 - Springer
The “golden era” of antibiotic discovery has long passed, but the need for new antibiotics
has never been greater due to the emerging threat of antibiotic resistance. This urgency to …
has never been greater due to the emerging threat of antibiotic resistance. This urgency to …
Clinical applications and anticancer effects of antimicrobial peptides: from bench to bedside
Cancer is a multifaceted global health issue and one of the leading causes of death
worldwide. In recent years, medical science has achieved great advances in the diagnosis …
worldwide. In recent years, medical science has achieved great advances in the diagnosis …