Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Background Neuropathic pain is one of the key features of (classical) Fabry disease (FD).
No randomized clinical trials comparing effectiveness of different pain management …

Introduction: Antiepileptic–antidepressant combinations are frequently used by clinicians;
their pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions (DIs) have not …

Abstract Introduction Adverse drug reactions (ADRs) are a major public health concern and
a leading cause of morbidity and mortality in the world. In the case of antiepileptic drugs …

Background. Epilepsy is one of the common neurological illnesses which affects millions of
individuals globally. Although the majority of epileptic patients have a good response for the …

Craniofacial skeletal anomalies are among the most common structural birth defects around
the world. Various studies using human populations and experimental animals have shown …

The zebrafish model is an attractive candidate for screening of developmental toxicity during
early drug development. Antiepileptic drugs (AEDs) arouse concern for the risk of …

Pharmaco-resistant epilepsies, and also some neuropsychiatric disorders, are often
associated with malformations in hippocampal and neocortical structures. The mechanisms …

Epilepsies are among the most common neurological problems. The disease burden in
patients with epilepsy is significantly high, and epilepsy has a huge negative impact on …

Valproic acid (VPA) is an anti-epileptic drug known to cause congenital craniofacial
abnormalities, including orofacial clefts (OFC). The exact mechanisms by which VPA leads …