The maternal pregnancy outcomes following the in-utero exposure to lamotrigine (LAMT), a
second-generation anticonvulsant medicine, have not been well elucidated. Lamotrigine is …

Objective Sodium valproate (VPA), the most effective antiepileptic drug for patients with
genetic generalized epilepsy (GGE), is a potent human teratogen that increases the risk of a …

Background Arsenic is widely distributed in the environment in both inorganic and organic
forms. Evidence from animal studies suggests that maternal inorganic arsenic may lead to …

Introduction: Drugs teratogenicity has been studied for many years, especially teratogenic
effects of antiepileptic drugs, because of the important impact that epilepsy has always had …

Abstract The draft Step 2 ICH S5 (R3) guideline includes an exposure-based endpoint as an
option for selecting the high-dose in reproductive and developmental toxicity studies. To …

Эпилепсия не является заболеванием, препятствующим беременности и родам. При
полном контроле над приступами возможно физиологическое протекание …

Topiramate is commonly used for treating epilepsy in both children and adults. Recent
clinical data suggests that administration of topiramate to women during pregnancy …

Recurrent, spontaneous seizure activity caused by abnormal neuronal firing in the brain is a
hallmark of epilepsy, a common chronic neurological disorder. Recent research that has …

Anti-epileptic drugs (AEDs) have high risk of teratogenic side effects, including neural tube
defects while mother is on AEDs for her own prevention of convulsions during pregnancy …

Hazard assessment of chemicals and pharmaceuticals is increasingly gaining from
knowledge about molecular mechanisms of toxic action acquired in dedicated in vitro …