Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches
for drug delivery applications. NPs main objective is to convey the therapeutic molecule be …

Magnetic nanoparticles in general, and iron oxide nanoparticles in particular, have been
studied extensively during the past 20 years for numerous biomedical applications. The …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Purpose To investigate the effects of the particle size and surface coating on the cellular
uptake of the polymeric nanoparticles for drug delivery across the physiological drug barrier …

Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs,
analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several …

d-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-
soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E …

The central nervous system (CNS) poses a unique challenge for drug delivery. The blood–
brain barrier significantly hinders the passage of systemically delivered therapeutics and the …

Although many agents have therapeutic potentials for central nervous system (CNS)
diseases, few of these agents have been clinically used because of the brain barriers. As the …

Prevailing opinion suggests that only substances up to 64 nm in diameter can move at
appreciable rates through the brain extracellular space (ECS). This size range is large …

The blood–brain barrier (BBB) presents a significant obstacle for the treatment of many
central nervous system (CNS) disorders, including invasive brain tumors, Alzheimer's …