[HTML][HTML] The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor
AB Elgoyhen - Pharmacological Research, 2023 - Elsevier
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …
Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor
Abstract α-Conotoxins are disulfide-rich and well-structured peptides, most of which can
block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency …
block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency …
Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain
We determined the X-ray crystal structures of the extracellular domain (ECD) of the
monomeric state of human neuronal α9 nicotinic acetylcholine receptor (nAChR) and of its …
monomeric state of human neuronal α9 nicotinic acetylcholine receptor (nAChR) and of its …
A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection
The transduction of sound in the auditory periphery, the cochlea, is inhibited by efferent
cholinergic neurons projecting from the brainstem and synapsing directly on …
cholinergic neurons projecting from the brainstem and synapsing directly on …
Determination of the α-conotoxin Vc1. 1 binding site on the α9α10 nicotinic acetylcholine receptor
α-Conotoxin Vc1. 1 specifically and potently inhibits the nicotinic acetylcholine receptor
subtype α9α10 (α9α10 nAChR) and is a potential novel treatment for neuropathic pain …
subtype α9α10 (α9α10 nAChR) and is a potential novel treatment for neuropathic pain …
α-Conotoxins to explore the molecular, physiological and pathophysiological functions of neuronal nicotinic acetylcholine receptors
J Giribaldi, S Dutertre - Neuroscience letters, 2018 - Elsevier
The vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and
peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable …
peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable …
α9-containing nicotinic receptors in cancer
Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …
Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA …
M Zouridakis, A Papakyriakou, IA Ivanov… - Frontiers in …, 2019 - frontiersin.org
The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in
heteropentameric assemblies with α10. Accumulating data indicate the presence of three …
heteropentameric assemblies with α10. Accumulating data indicate the presence of three …
Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro
L Koval, O Lykhmus, M Zhmak, A Khruschov… - The international journal …, 2011 - Elsevier
Mouse B lymphocytes express several nicotinic acetylcholine receptor (nAChR) subtypes,
their exact functions being not clearly understood. Here we show that α7 nAChR was …
their exact functions being not clearly understood. Here we show that α7 nAChR was …
The efferent medial olivocochlear-hair cell synapse
AB Elgoyhen, E Katz - Journal of Physiology-Paris, 2012 - Elsevier
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which
travels back from the brain all the way to the cochlea. The medial olivocochlear system …
travels back from the brain all the way to the cochlea. The medial olivocochlear system …