The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model
SD AlSharari, W Toma, HM Mahmood… - European journal of …, 2020 - Elsevier
Nicotinic acetylcholine receptors can regulate inflammation primarily through the vagus
nerve via the cholinergic anti-inflammatory pathway. α9α10 nicotinic receptors (nAChRs) are …
nerve via the cholinergic anti-inflammatory pathway. α9α10 nicotinic receptors (nAChRs) are …
Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor
M Lipovsek, GJ Im, LF Franchini… - Proceedings of the …, 2012 - National Acad Sciences
The α9 and α10 cholinergic nicotinic receptor subunits assemble to form the receptor that
mediates efferent inhibition of hair cell function within the auditory sensory organ, a …
mediates efferent inhibition of hair cell function within the auditory sensory organ, a …
Nicotinic acetylcholine receptor α9 and α10 subunits are expressed in the brain of mice
O Lykhmus, LP Voytenko, KS Lips, I Bergen… - Frontiers in Cellular …, 2017 - frontiersin.org
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the
evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels …
evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels …
Molecular determinants conferring the stoichiometric-dependent activity of α-conotoxins at the human α9α10 nicotinic acetylcholine receptor subtype
α9α10 nicotinic acetylcholine receptors (nAChRs) putatively exist at different stoichiometries.
We systematically investigated the molecular determinants of α-conotoxins Vc1. 1, RgIA# …
We systematically investigated the molecular determinants of α-conotoxins Vc1. 1, RgIA# …
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
S Xu, T Zhang, SN Kompella, M Yan, A Lu, Y Wang… - Scientific Reports, 2015 - nature.com
Nicotinic acetylcholine receptors (nAChRs) play essential roles in transmitting acetylcholine-
mediated neural signals across synapses and neuromuscular junctions and are also closely …
mediated neural signals across synapses and neuromuscular junctions and are also closely …
Nicotinic acetylcholine receptor ligands, a patent review (2006–2011)
D Gündisch, C Eibl - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Nicotinic acetylcholine receptors (nAChRs), pentameric ligand-gated cation
channels, are potential targets for the development of therapeutics for a variety of disease …
channels, are potential targets for the development of therapeutics for a variety of disease …
Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic …
H Andleeb, RL Papke, C Stokes, K Richter… - Journal of Medicinal …, 2024 - ACS Publications
There is an urgent need for nonopioid treatments for chronic and neuropathic pain to
provide effective alternatives amid the escalating opioid crisis. This study introduces novel …
provide effective alternatives amid the escalating opioid crisis. This study introduces novel …
Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1. 1
DC Indurthi, E Pera, HL Kim, C Chu, MD McLeod… - Biochemical …, 2014 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in fast
synaptic transmission. nAChRs are pentameric receptors formed from a combination of …
synaptic transmission. nAChRs are pentameric receptors formed from a combination of …
Calcium signaling in the cochlea–Molecular mechanisms and physiopathological implications
Abstract Calcium ions (Ca 2+) regulate numerous and diverse aspects of cochlear and
vestibular physiology. This review focuses on the Ca 2+ control of mechanotransduction and …
vestibular physiology. This review focuses on the Ca 2+ control of mechanotransduction and …
When learning and remembering compete: a functional MRI study
Recent functional neuroimaging evidence suggests a bottleneck between learning new
information and remembering old information. In two behavioral experiments and one …
information and remembering old information. In two behavioral experiments and one …