Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …

Depression is a well-known serious mental illness, and the onset of treatment using
traditional antidepressants is frequently delayed by several weeks. Moreover, numerous …

Excitatory signaling mediated by N-methyl-d-aspartate receptor (NMDAR) is critical for brain
development and function, as well as for neurological diseases and disorders. Channel …

The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …

Neurotransmission mediated by diverse subtypes of N-methyl-D-aspartate receptors
(NMDARs) is fundamental for basic brain functions and development as well as …

Background: Due to its unique physical and chemical properties, lead is still used worldwide
in several applications, especially in industry. Both environmental and industrial lead …

Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional
antidepressants usually require several weeks of continuous administration to exert …

Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Abstract N-methyl-d-aspartate (NMDA) receptors are heterotetramers comprising two GluN1
and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures …