Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …

Translocator protein (TSPO) is an 18kDa high affinity cholesterol-and drug-binding protein
found primarily in the outer mitochondrial membrane. Although TSPO is found in many …

The deposition of the amyloid β (Aβ) peptide in neuritic plaques plays a critical role in the
pathogenesis of Alzheimer's disease (AD). Aβ is generated through the proteolysis of …

There is strong evidence that protein kinase C (PKC) isozyme signaling pathways are
causally involved in associative memory storage. Other observations have indicated that …

Protein kinase C (PKC) is involved in synaptic remodeling, induction of protein synthesis,
and many other processes important in learning and memory. Activation of neuronal protein …

Microglia transform from homeostatic to disease‐associated‐microglia (DAM) profiles in
neurodegeneration. Within DAM, we recently identified distinct pro‐inflammatory and anti …

Currently available diagnostic tests have moved the field closer to early diagnosis of
Alzheimer's disease (AD); however, a definitive diagnosis is made only with the …

Neurological disorders are found to be influencing the peripheral tissues outside CNS.
Recent developments in biomarkers for CNS have emerged with various diagnostic and …