Protein degraders are emerging as potent therapeutic tools to address neurological
disorders and many complex diseases. It offered several key advantages, including the …

Huntington's disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat
expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction …

Title. Proteolysis targeting chimeric (PROTAC) compound with E3 ubiquitin ligase binding
activity and targeting alphasynuclein protein for treating neurovegetative diseases. Patent …

Abstract Purpose of Review This article describes and discusses new potential disease-
modifying therapies for Huntington's disease that are currently in human clinical trials as well …

Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …

Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by a
mutation in the huntingtin (HTT) gene, resulting in the production of a mutant huntingtin …

Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …

Neurodegenerative diseases (NDDs) are characterized by progressive deterioration of the
structure and function of cells and their networks in the nervous system. There are currently …

Abstract Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modify the gene
expression through histone deacetylation. SIRT1 plays a crucial role in regulating a wide …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
pathogenic expansions of the triplet cytosine-adenosine-guanosine (CAG) within the …