Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity
of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …

Coronin 1C is overexpressed in multiple tumors, leading to the widely held view that this
gene drives tumor progression, but this hypothesis has not been rigorously tested in …

As wider insights are gained on the molecular landscape of triple-negative breast cancer
(TNBC), novel targeted therapeutic strategies might become an option in this setting as well …

Biological pathways reflect the key cellular mechanisms that dictate disease states, drug
response and altered cellular function. The local areas of pathways are defined as …

Background Whole-genome doubling (WGD) has been observed in 30% of cancers,
followed by a highly complex rearranged karyotype unfavourable to breast cancer's …

Background The main challenge in cancer research is the identification of different omic
variables that present a prognostic value and personalised diagnosis for each tumour. The …

Background Genomic insights in settings where tumour sample sizes are limited to just
hundreds or even tens of cells hold great clinical potential, but also present significant …

Pharmacogenomics is an evolving tool of precision medicine. Recently, due to the
introduction of next-generation sequencing and projects generating “Big Data”, a plethora of …

Aberrant expression of meiosis-specific genes in cancer has recently emerged as a driver of
some cancer formation. Aurora kinase C (AURKC) is a member of the Aurora kinase family …

We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain
(PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR+/HER2−) breast …