Pharmacogenomics is an evolving tool of precision medicine. Recently, due to the
introduction of next-generation sequencing and projects generating “Big Data”, a plethora of …

Aberrant expression of meiosis-specific genes in cancer has recently emerged as a driver of
some cancer formation. Aurora kinase C (AURKC) is a member of the Aurora kinase family …

We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain
(PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR+/HER2−) breast …

Cancer is a disease often characterized by the presence of multiple genomic alterations,
which trigger altered transcriptional patterns and gene expression, which in turn sustain the …

The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps
control chromosome separation and exit from mitosis in many different kinds of organisms …

Accurate survival prediction is crucial for doctors to choose appropriate treatment options
and make prognoses for gastric cancer patients. While machine learning algorithms have …

Metastasis is the leading cause of mortality in cancer patients. Underlying this process is the
invasion and colonization of cancer cells into healthy tissues. Engineered hydrogel models …

Emerging data indicate that genomic alterations can shape immune cell composition in early
breast cancer. However, there is a need for complementary imaging and sequencing …

Esophageal squamous cell carcinoma (ESCC) is a malignant tumor that commonly occurs
worldwide. Usually, Asia, especially China, has a high incidence of esophageal cancer …

Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a
large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration …