Use of newer and repurposed antibiotics against gram-negative bacteria in neonates
Antimicrobial resistance has become a significant public health problem globally with
multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The …
multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The …
Uncertainty in antibiotic dosing in critically ill neonate and pediatric patients: can microsampling provide the answers?
T Dorofaeff, RM Bandini, J Lipman, DE Ballot… - Clinical …, 2016 - Elsevier
Purpose With a decreasing supply of antibiotics that are effective against the pathogens that
cause sepsis, it is critical that we learn to use currently available antibiotics optimally …
cause sepsis, it is critical that we learn to use currently available antibiotics optimally …
Population pharmacokinetics and dosing optimization of azlocillin in neonates with early-onset sepsis: a real-world study
YE Wu, T Wang, HL Yang, BH Tang… - Journal of …, 2021 - academic.oup.com
Objectives Nowadays, real-world data can be used to improve currently available dosing
guidelines and to support regulatory approval of drugs for use in neonates by overcoming …
guidelines and to support regulatory approval of drugs for use in neonates by overcoming …
Neonates are not just little children and need more finesse in dosing of antibiotics
K Allegaert, J van den Anker - Acta Clinica Belgica, 2019 - Taylor & Francis
Objectives: Neonates are not just little children. They need more finesse in decisions on
when to treat, which antibiotics to use and how to dose these antibiotics. Methods …
when to treat, which antibiotics to use and how to dose these antibiotics. Methods …
Clinical pharmacology of carbapenems in neonates
GM Pacifici, K Allegaert - Journal of Chemotherapy, 2014 - Taylor & Francis
Carbapenems are an effective tool to treat complicated bacterial infections. This review aims
to summarize the available information on carbapenems in neonates to guide clinicians on …
to summarize the available information on carbapenems in neonates to guide clinicians on …
A Delphi process to optimize quality and performance of drug evaluation in neonates
F Legrand, R Boulkedid, V Elie, S Leroux, E Valls… - Plos one, 2014 - journals.plos.org
Background Neonatal trials remain difficult to conduct for several reasons: in particular the
need for study sites to have an existing infrastructure in place, with trained investigators and …
need for study sites to have an existing infrastructure in place, with trained investigators and …
[HTML][HTML] Analysis of Paediatric Clinical Trial Characteristics and Activity Over 23 Years—Impact of the European Paediatric Regulation on a Single French Clinical …
J Arnadottir, F Luc, F Kaguelidou… - Frontiers in …, 2022 - frontiersin.org
As unlicensed or off-label drugs are frequently prescribed in children, the European
Paediatric Regulation came into force in 2007 to improve the safe use of medicinal products …
Paediatric Regulation came into force in 2007 to improve the safe use of medicinal products …
Posologie des antibiotiques chez le nouveau-né: variations des pratiques et comment y remédier?
S Leroux, W Zhao, V Biran, E Jacqz-Aigrain - Archives de Pédiatrie, 2016 - Elsevier
Résumé La prescription néonatale des antibiotiques pose le problème d'une grande
variabilité de pratiques tant au niveau national qu'international. Ceci reflète un manque …
variabilité de pratiques tant au niveau national qu'international. Ceci reflète un manque …