Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …

The use of continuous infusion to improve the therapeutic efficacy of time-dependent
antibiotics has been demonstrated. There is still a lack of data to safely perform these …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among
Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Objective: Piperacillin-tazobactam is a commonly used antibiotic in critically ill patients;
however, controversy exists as to whether mortality in serious infections can be decreased …

Purpose Optimization of antibiotic therapy is still urgently needed in critically ill patients. The
aim of the ONTAI survey (online survey on the use of Therapeutic Drug Monitoring of …

Abstract Background Ceftolozane-tazobactam (TOL-TAZ) affords broad coverage against
Pseudomonas aeruginosa. Regrettably, TOL-TAZ resistance has been reported. We sought …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

Introduction Continuous infusion (CI) of beta-lactam antibiotics may be of benefit in some
patients, particularly those with severe infections. However, most studies have been small …