Drugs are key weapons that clinicians have to battle against the profound pathologies
encountered in critically ill patients. Antibiotics in particular are commonly used and can …

Background Critically ill patients display altered pharmacokinetics and pharmacodynamics
and are more likely to be infected with more resistant pathogens. Beta-lactam antibiotics …

In the past decade, the prevalence of multidrug-resistant gram-negative (MDR-GN) bacterial
infections has increased significantly, leading to higher rates of morbidity and mortality …

Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host
response to infection with a hospital mortality in excess of 40%. Along with insufficient and …

This objective of this study was to compare clinical outcomes in hospitalized patients with
Pseudomonas aeruginosa pneumonia (PNA) or bloodstream infection (BSI) receiving beta …

Background In recent years, numerous dosing studies have been conducted to optimize
therapeutic antibiotic exposures in patients with serious infections. These studies have led to …

Antimicrobial prescription in critically ill patients represents a complex challenge due to the
difficult balance between infection treatment and toxicity prevention. Underexposure to …

Objectives To assess the role that real-time therapeutic drug monitoring (TDM)-guided
optimization of continuous-infusion (CI) meropenem may have in maximizing empirical …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Augmented renal clearance (ARC) is a phenomenon of increased renal function in patients
with risk factors. Sub-therapeutic drug concentrations and antibacterial exposure in ARC …