Analysis of HLA Variants and Graves' Disease and Its Comorbidities Using a High Resolution Imputation System to Examine Electronic Medical Health Records
Hyperthyroidism is a prevalent endocrine disorder, and genetics play a major role in the
development of thyroid-associated diseases. In particular, the inheritance of HLA has been …
development of thyroid-associated diseases. In particular, the inheritance of HLA has been …
Genome-wide association study of alopecia areata in Taiwan: The conflict between individuals and hair follicles
Purpose Alopecia areata (AA) is one of the most prevalent autoimmune diseases affecting
humans. Given that hair follicles are immune-privileged, autoimmunity can result in …
humans. Given that hair follicles are immune-privileged, autoimmunity can result in …
Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population
Aims To analyse the genome‐wide association study (GWAS) data of patients with type 1
diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk …
diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk …
A genome-wide association study identified novel genetic susceptibility loci for oral cancer in Taiwan
Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is
mostly an environmentally induced cancer, genetic factors also play an important role in its …
mostly an environmentally induced cancer, genetic factors also play an important role in its …
Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan
Excess thyroid hormones have complex metabolic effects, particularly hyperthyroidism, and
are associated with various cardiovascular risk factors. Previous candidate gene studies …
are associated with various cardiovascular risk factors. Previous candidate gene studies …
Effects of human leukocyte antigen drb1 genetic polymorphism on anti-cyclic citrullinated peptide (ANTI-CCP) and rheumatoid factor (RF) expression in rheumatoid …
YC Chen, CM Huang, TY Liu, N Wu, CJ Chan… - International Journal of …, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a systemic disease characterized by non-infectious
inflammation of the joints and surrounding tissues, which can cause severe health problems …
inflammation of the joints and surrounding tissues, which can cause severe health problems …
Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling
Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated
polygenic scores across 457 phenotypes using genotyping array data from China Medical …
polygenic scores across 457 phenotypes using genotyping array data from China Medical …
Comprehensive characterization of pharmacogenes in a Taiwanese Han population
Pharmacogenetic (PGx) testing has not been well adopted in current clinical practice. The
phenotypic distribution of clinically relevant pharmacogenes remains to be fully …
phenotypic distribution of clinically relevant pharmacogenes remains to be fully …
The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases
Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and
several genome-wide association studies (GWASs) have demonstrated the association …
several genome-wide association studies (GWASs) have demonstrated the association …
Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese …
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) describes a group of
progressive lung diseases causing breathing difficulties. While COPD development typically …
progressive lung diseases causing breathing difficulties. While COPD development typically …