An Exploration of Analgesia Options for Australian Sheep

S Cohen, E Foss, T Beths, GC Musk - Animals, 2024 - mdpi.com
Simple Summary Sheep may undergo a variety of painful husbandry and disease processes
in their lifetime, which negatively impact their welfare. These procedures can cause …

[HTML][HTML] Epidural oxycodone for acute pain

P Piirainen, H Kokki, M Kokki - Pharmaceuticals, 2022 - mdpi.com
Epidural analgesia is commonly used in labour analgesia and in postoperative pain after
major surgery. It is highly effective in severe acute pain, has minimal effects on foetus and …

[HTML][HTML] Central nervous system distribution of buprenorphine in pregnant sheep, fetuses and newborn lambs after continuous transdermal and single subcutaneous …

H Hakomäki, S Eskola, H Kokki, M Lehtonen… - European Journal of …, 2022 - Elsevier
Buprenorphine is used during pregnancy for the treatment of opioid use disorder. Limited
data exist on the central nervous system (CNS) permeation and distribution, and on the fetal …

[HTML][HTML] ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein

W Qin, L Zhang, X Wang, B Liu, L Xu, L Liu… - Biomedicine & …, 2024 - Elsevier
The association between polymorphisms of the human ATP binding cassette subfamily B
member 1 (ABCB1) gene and opioid response has attracted intense attention recently. As …

[HTML][HTML] A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues

A Manca, A De Nicolò, ED De Vivo, M Ferrara, S Oh… - Pharmaceuticals, 2023 - mdpi.com
Background: Opioids are considered the cornerstone of pain management: they show good
efficacy as a first-line therapy for moderate to severe cancer pain. Since pharmacokinetic …

[PDF][PDF] Buprenorphine in pregnant sheep: maternal pharmacokinetics, fetal exposure, and central nervous system distribution

H Hakomäki - 2023 - erepo.uef.fi
Buprenorphine (BUP) is an opioid analgesic used during pregnancy in the treatment of
opioid use disorder. Opioid abuse during pregnancy is associated with an increased risk of …