[HTML][HTML] Natural hydrogel-based bio-inks for 3D bioprinting in tissue engineering: A review

A Fatimi, OV Okoro, D Podstawczyk, J Siminska-Stanny… - Gels, 2022 - mdpi.com
Three-dimensional (3D) printing is well acknowledged to constitute an important technology
in tissue engineering, largely due to the increasing global demand for organ replacement …

Emerging tumor-on-chips with electrochemical biosensors

L Lei, B Ma, C Xu, H Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications

G Bhattacharjee, N Gohil, K Khambhati, I Mani… - Journal of Controlled …, 2022 - Elsevier
A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …

Evaluation of proton-induced DNA damage in 3D-engineered glioblastoma microenvironments

Q Akolawala, M Rovituso, HH Versteeg… - … applied materials & …, 2022 - ACS Publications
Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis.
For this reason, besides clinical and preclinical studies, novel in vitro models for the …

[PDF][PDF] In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications

MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …

Evaluation of biological activity of natural compounds: Current trends and methods

C Barba-Ostria, SE Carrera-Pacheco… - Molecules, 2022 - mdpi.com
Natural compounds have diverse structures and are present in different forms of life.
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …

[HTML][HTML] Hydrogel-based microfluidic device with multiplexed 3D in vitro cell culture

A Clancy, D Chen, J Bruns, J Nadella, S Stealey… - Scientific Reports, 2022 - nature.com
Microfluidic devices that combine an extracellular matrix environment, cells, and
physiologically relevant perfusion, are advantageous as cell culture platforms. We …

[HTML][HTML] The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: A review

V Carvalho, M Bañobre-López, G Minas, SFCF Teixeira… - Bioprinting, 2022 - Elsevier
Every year, cancer causes millions of deaths around the globe, and researchers have been
engaged to provide novel therapies for this threatening disease. However, this process is …

[HTML][HTML] Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …