[HTML][HTML] Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

H Lasolle, A Schiavo, A Tourneur, P Gillotay… - Oncogene, 2024 - nature.com
Thyroid cancer is the most common endocrine malignancy and several genetic events have
been described to promote the development of thyroid carcinogenesis. Besides the effects of …

[HTML][HTML] Human Lung Organoids—A Novel Experimental and Precision Medicine Approach

L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

[HTML][HTML] Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models

S Brandl, M Reindl - International Journal of Molecular Sciences, 2023 - mdpi.com
The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

[HTML][HTML] NGAL as a potential target in tumor microenvironment

E Crescenzi, A Leonardi, F Pacifico - International Journal of Molecular …, 2021 - mdpi.com
The signaling network between cancer and stromal cells plays a crucial role in tumor
microenvironment. The fate of tumor progression mainly depends on the huge amount of …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …

[HTML][HTML] Organoid technology: A reliable developmental biology tool for organ-specific nanotoxicity evaluation

M Prasad, R Kumar, L Buragohain, A Kumari… - Frontiers in cell and …, 2021 - frontiersin.org
Engineered nanomaterials are bestowed with certain inherent physicochemical properties
unlike their parent materials, rendering them suitable for the multifaceted needs of state-of …

Recent advances in liver‐on‐chips: Design, fabrication, and applications

L Qiu, B Kong, T Kong, H Wang - Smart Medicine, 2023 - Wiley Online Library
The liver is a multifunctional organ and the metabolic center of the human body. Most drugs
and toxins are metabolized in the liver, resulting in varying degrees of hepatotoxicity. The …

[HTML][HTML] 3D cancer models: Depicting cellular crosstalk within the tumour microenvironment

T Franchi-Mendes, R Eduardo, G Domenici, C Brito - Cancers, 2021 - mdpi.com
Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

[HTML][HTML] NAFLD-related HCC: focus on the latest relevant preclinical models

J Fang, S Celton-Morizur, C Desdouets - Cancers, 2023 - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging
from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH), which can progress to …

Lipidomic Phenotyping Of Human Small Intestinal Organoids Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

AAM Duivenvoorden, BSR Claes… - Analytical …, 2023 - ACS Publications
In the past decade, interest in organoids for biomedical research has surged, resulting in a
higher demand for advanced imaging techniques. Traditional specimen embedding …