Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity
are common challenges of the existing therapies, making the development of reliable …

Herbivorous insects encounter diverse plant specialized metabolites (PSMs) in their diet,
that have deterrent, anti-nutritional, or toxic properties. Understanding how they cope with …

The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …

Patient-derived tumour organoids (PDOs) have revolutionised our understanding of cancer
biology and the applications of personalised therapies. These advancements are principally …

Lung cancer is one of the most aggressive and deadliest health threats. There has been an
increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of …

Organoids are three-dimensional in vitro cell constructs that recapitulate organ properties
and structure to a significant extent. They constitute particularly useful models to study …

The five-year overall survival rate remains about 50% for head and neck cancer patients
even though new cancer drugs have been approved for clinical use since 2016. Cancer …

The increasing use of medical implants in various areas of medicine, particularly in
orthopedic surgery, oncology, cardiology and dentistry, displayed the limitations in long-term …

Metabolomics, the study of metabolites present in biological samples, can provide a global
view of sample state as well as insights into biological changes caused by disease or …