So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

The ketogenic diet (KD) has been used as a treatment for epilepsy since the 1920s, and its
role in the prevention of many other diseases is now being considered. In recent years, there …

Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …

Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of
physiology and thus have been targeted as therapeutics for several diseases including …

The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …

The therapeutic potential of natural stilbenes, with a particular focus on pterostilbene (PTE),
has emerged as a promising avenue of research targeting age-associated conditions …

A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease caused by upper
and lower motor neuron death. Despite advances in our understanding of ALS …