Current concepts of neurodegenerative mechanisms in Alzheimer's disease

KB Magalingam, A Radhakrishnan… - BioMed research …, 2018 - Wiley Online Library
Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

[HTML][HTML] The epigenetics of Alzheimer's disease: factors and therapeutic implications

X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …

[HTML][HTML] Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms

P Li, L Marshall, G Oh, JL Jakubowski, D Groot… - Nature …, 2019 - nature.com
Epigenetic control of enhancers alters neuronal functions and may be involved in
Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by …

[HTML][HTML] Epigenetic alterations in Alzheimer's disease

JV Sanchez-Mut, J Gräff - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

[HTML][HTML] Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

JV Sanchez-Mut, H Heyn, E Vidal, S Moran… - Translational …, 2016 - nature.com
Different neurodegenerative disorders often show similar lesions, such as the presence of
amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited …

Epigenomics of Alzheimer's disease

DA Bennett, L Yu, J Yang, HU Klein… - Translating Epigenetics to …, 2017 - Elsevier
Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …

[HTML][HTML] Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease

AA Balmik, S Chinnathambi - Cell Communication and Signaling, 2021 - Springer
Neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease
involves abnormal aggregation and accumulation of toxic proteins aggregates. Post …

β-Amyloid peptide: The cell compartment multi-faceted interaction in Alzheimer's disease

P Picone, D Nuzzo, D Giacomazza, M Di Carlo - Neurotoxicity research, 2020 - Springer
Alzheimer's disease (AD) is the most widespread form of dementia, characterized by
memory loss and reduction of cognitive functions that strongly interfere with normal daily life …

[HTML][HTML] An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases

X Huang, G Wong - Translational Neurodegeneration, 2021 - Springer
PIWI-interacting RNAs (piRNAs) are small non-coding transcripts that are highly conserved
across species and regulate gene expression through pre-and post-transcriptional …

[HTML][HTML] DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer's, related tauopathies and genetic tauopathies

G Zimmer-Bensch, H Zempel - Cells, 2021 - mdpi.com
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …