Current concepts of neurodegenerative mechanisms in Alzheimer's disease
KB Magalingam, A Radhakrishnan… - BioMed research …, 2018 - Wiley Online Library
Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …
progressive loss of the structure and function of neurons as well as neuronal death …
[HTML][HTML] The epigenetics of Alzheimer's disease: factors and therapeutic implications
X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
[HTML][HTML] Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms
Epigenetic control of enhancers alters neuronal functions and may be involved in
Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by …
Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by …
[HTML][HTML] Epigenetic alterations in Alzheimer's disease
JV Sanchez-Mut, J Gräff - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …
asymptomatically during decades before being belatedly diagnosed when therapeutic …
[HTML][HTML] Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
Different neurodegenerative disorders often show similar lesions, such as the presence of
amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited …
amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited …
Epigenomics of Alzheimer's disease
Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …
[HTML][HTML] Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease
AA Balmik, S Chinnathambi - Cell Communication and Signaling, 2021 - Springer
Neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease
involves abnormal aggregation and accumulation of toxic proteins aggregates. Post …
involves abnormal aggregation and accumulation of toxic proteins aggregates. Post …
β-Amyloid peptide: The cell compartment multi-faceted interaction in Alzheimer's disease
Alzheimer's disease (AD) is the most widespread form of dementia, characterized by
memory loss and reduction of cognitive functions that strongly interfere with normal daily life …
memory loss and reduction of cognitive functions that strongly interfere with normal daily life …
[HTML][HTML] An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases
PIWI-interacting RNAs (piRNAs) are small non-coding transcripts that are highly conserved
across species and regulate gene expression through pre-and post-transcriptional …
across species and regulate gene expression through pre-and post-transcriptional …
[HTML][HTML] DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer's, related tauopathies and genetic tauopathies
G Zimmer-Bensch, H Zempel - Cells, 2021 - mdpi.com
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …