[HTML][HTML] Marine-derived drugs: Recent advances in cancer therapy and immune signaling
AFUH Saeed, J Su, S Ouyang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The marine environment is an enormous source of marine-derived natural products (MNPs),
and future investigation into anticancer drug discovery. Current progress in anticancer drugs …
and future investigation into anticancer drug discovery. Current progress in anticancer drugs …
Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)
Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …
Compounds from natural sources as protein kinase inhibitors
The advantage of natural compounds is their lower number of side-effects when compared
to most synthetic substances. Therefore, over the past several decades, the interest in …
to most synthetic substances. Therefore, over the past several decades, the interest in …
Structural manipulations of marine natural products inspire a new library of 3-amino-1, 2, 4-triazine PDK inhibitors endowed with antitumor activity in pancreatic ductal …
D Carbone, M De Franco, C Pecoraro, D Bassani… - Marine Drugs, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer,
characterized by late prognosis and drug resistance. Among the main factors sustaining …
characterized by late prognosis and drug resistance. Among the main factors sustaining …
In silico prediction of steroids and triterpenoids as potential regulators of lipid metabolism
VM Dembitsky - Marine Drugs, 2021 - mdpi.com
This review focuses on a rare group of steroids and triterpenoids that share common
properties as regulators of lipid metabolism. This group of compounds is divided by the type …
properties as regulators of lipid metabolism. This group of compounds is divided by the type …
Targeting cyclin‐dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies
Abstract Cyclin‐dependent kinase 6 (CDK6) is a member of serine/threonine kinase family,
and its overexpression is associated with cancer development. Thus, it is considered as a …
and its overexpression is associated with cancer development. Thus, it is considered as a …
Drug repurposing and de novo drug discovery of protein kinase inhibitors as new drugs against schistosomiasis
B Pereira Moreira, MHW Weber, S Haeberlein… - Molecules, 2022 - mdpi.com
Schistosomiasis is a neglected tropical disease affecting more than 200 million people
worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but …
worldwide. Chemotherapy relies on one single drug, praziquantel, which is safe but …
Natural products of marine origin for the treatment of colorectal and pancreatic cancers: mechanisms and potential
N Fares Amer, T Luzzatto Knaan - International Journal of Molecular …, 2022 - mdpi.com
Gastrointestinal cancer refers to malignancy of the accessory organs of digestion, and it
includes colorectal cancer (CRC) and pancreatic cancer (PC). Worldwide, CRC is the …
includes colorectal cancer (CRC) and pancreatic cancer (PC). Worldwide, CRC is the …
Computational approaches to enzyme inhibition by marine natural products in the search for new drugs
F Gago - Marine Drugs, 2023 - mdpi.com
The exploration of biologically relevant chemical space for the discovery of small bioactive
molecules present in marine organisms has led not only to important advances in certain …
molecules present in marine organisms has led not only to important advances in certain …
Antitumor potential of seaweed derived-endophytic fungi
The marine environment presents a high biodiversity and a valuable source of bioactive
compounds with therapeutic and biotechnological potential. Among the organisms present …
compounds with therapeutic and biotechnological potential. Among the organisms present …