Artificial Intelligence-based Amide-II Infrared Spectroscopy Simulation for Monitoring Protein Hydrogen Bonding Dynamics
The structurally sensitive amide II infrared (IR) bands of proteins provide valuable
information about the hydrogen bonding of protein secondary structures, which is crucial for …
information about the hydrogen bonding of protein secondary structures, which is crucial for …
Misfolding of a human islet amyloid polypeptide at the lipid membrane populates through β-sheet conformers without involving α-helical intermediates
Amyloid formation has been implicated in many fatal diseases, but its mechanism remains to
be clarified due to a lack of effective methods that can capture the transient intermediates …
be clarified due to a lack of effective methods that can capture the transient intermediates …
Raman Spectroscopic Insights of Phase-Separated Insulin Aggregates
Phase-separated protein accumulation through the formation of several aggregate species
is linked to the pathology of several human disorders and diseases. Our current …
is linked to the pathology of several human disorders and diseases. Our current …
Order, disorder, and reorder state of lysozyme: aggregation mechanism by Raman spectroscopy
Lysozyme, like many other well-folded globular proteins, under stressful conditions
produces nanoscale oligomer assembly and amyloid-like fibrillar aggregates. With engaging …
produces nanoscale oligomer assembly and amyloid-like fibrillar aggregates. With engaging …
Conformational evolution of molecular signatures during amyloidogenic protein aggregation
G Devitt, W Rice, A Crisford… - ACS chemical …, 2019 - ACS Publications
Aggregation is a pathological hallmark of proteinopathies such as Alzheimer's disease and
results in the deposition of β-sheet-rich amyloidogenic protein aggregates. Such …
results in the deposition of β-sheet-rich amyloidogenic protein aggregates. Such …
Intrinsic origin of amyloid aggregation: Behavior of histidine (εεε) and (δδδ) tautomer homodimers of Aβ (1–40)
Amyloid-beta protein (Aβ) accumulation in the brain, which is influenced by several factors,
is a hallmark of Alzheimer's disease (AD). Despite the important role of histidine in …
is a hallmark of Alzheimer's disease (AD). Despite the important role of histidine in …
Structural insight of amyloidogenic intermediates of human insulin
Engaging Raman spectroscopy as a primary tool, we investigated the early events of insulin
fibrilization and determined the structural content present in oligomer and protofibrils that are …
fibrilization and determined the structural content present in oligomer and protofibrils that are …
Application of the double-mutant cycle strategy to protein aggregation reveals transient interactions in amyloid-β Oligomers
Transient oligomeric intermediates in the peptide or protein aggregation pathway are
suspected to be the key toxic species in many amyloid diseases, but deciphering their …
suspected to be the key toxic species in many amyloid diseases, but deciphering their …
Carvedilol inhibits Aβ25-35 fibrillation by intervening the early stage helical intermediate formation: a biophysical investigation
Self-assembly of disordered amyloid-beta (Aβ) peptides results in highly ordered amyloid
fibrils. The structural information of the early-stage events and also in the presence of …
fibrils. The structural information of the early-stage events and also in the presence of …
Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations
The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized
as a key player in the pathogenesis of Alzheimer's disease. Recent experiments reported …
as a key player in the pathogenesis of Alzheimer's disease. Recent experiments reported …