Apolipoprotein E and Alzheimer's disease: findings, hypotheses, and potential mechanisms
N Koutsodendris, MR Nelson, A Rao… - Annual Review of …, 2022 - annualreviews.org
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …
[HTML][HTML] New insights into the pathogenesis of Alzheimer's disease
L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
[PDF][PDF] Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition
AJ Martorell, AL Paulson, HJ Suk, F Abdurrob… - Cell, 2019 - cell.com
We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …
neurological disorders. However, the relationship between gamma oscillations and cellular …
Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation
HR Joo, LM Frank - Nature Reviews Neuroscience, 2018 - nature.com
Various cognitive functions have long been known to require the hippocampus. Recently,
progress has been made in identifying the hippocampal neural activity patterns that …
progress has been made in identifying the hippocampal neural activity patterns that …
[HTML][HTML] Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral …
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral …
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease
K Richetin, P Steullet, M Pachoud, R Perbet… - Nature …, 2020 - nature.com
Alzheimer's disease (AD) is characterized by the accumulation of the tau protein in neurons,
neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain …
neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain …
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies,
only to fail in human trials, suggesting a pressing need to study AD in human model …
only to fail in human trials, suggesting a pressing need to study AD in human model …
[PDF][PDF] Gamma entrainment binds higher-order brain regions and offers neuroprotection
Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …