Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …

Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …

Catalysis and medicine are often considered as two independent research fields with their
own respective scientific phenomena. Promoted by recent advances in nanochemistry, large …

Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Condensed states of proteins, including liquid-like membraneless organelles and solid-like
aggregates, contribute in fundamental ways to the organisation and function of the cell …

Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …