Abstract Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts
glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 …

Middle ear cholesteatoma (MEC), is a destructive, and locally invasive lesion in the middle
ear driven by inflammation with an annual incidence of 10 per 100,000. Surgical …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial joint
hyperplasia, joint inflammation, cartilage erosion and bone destruction. Macrophages play …

Inflammation is a major risk factor for osteoporosis, and reducing inflammatory levels is
important for the prevention of osteoporosis. Although nuclear receptor 77 (Nur77) protects …

Immune checkpoint blockade has emerged as a significant therapeutic development in
immunotherapy during the past decade. However, only a small percentage of cancer …

Highlights•NTZ dose-dependently inhibits the proliferation, migration and invasion of RA-
FLS.•NTZ prevents cell cycle progression and inflammatory cytokines mRNA …

Severe interstitial lung disease secondary to connective tissue diseases, characterized by
pulmonary inflammation and fibrosis, often have very poor prognosis due to lack of effective …

Kaempferol (KP), as a natural anti‐inflammatory compound, has been reported to have
curative effects on alleviating senile osteoporosis (SOP), which is an inflammation‐related …

Background. Influence of iguratimod on bone mineral density (BMD) and biomarkers of bone
metabolism in patients with rheumatoid arthritis (RA) remains not determined. Accordingly, a …

Background The inadequate response of some patients with rheumatoid arthritis (RA) to
current therapies is an issue that needs to be addressed. Patients with refractory RA (RRA) …