[HTML][HTML] Metabolomics-based development of bioproduction processes toward industrial-scale production
Highlights•Metabolomics accelerates bioproduction via strain, culture, and model
improvement.•Metabolomics is a powerful driving force for the DBTL-based strain …
improvement.•Metabolomics is a powerful driving force for the DBTL-based strain …
[HTML][HTML] Multi-omics view of recombinant Yarrowia lipolytica: Enhanced ketogenic amino acid catabolism increases polyketide-synthase-driven docosahexaenoic …
SJ Gasovic, D Dietrich, L Gläser, P Cao… - Metabolic …, 2023 - Elsevier
DHA is a marine PUFA of commercial value, given its multiple health benefits. The
worldwide emerging shortage in DHA supply has increased interest in microbial cell …
worldwide emerging shortage in DHA supply has increased interest in microbial cell …
[HTML][HTML] Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and …
D Dietrich, S Jovanovic-Gasovic, P Cao… - Microbial Cell …, 2023 - Springer
Background Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic
acid (DHA), are essential for human health and have been widely used in the food and …
acid (DHA), are essential for human health and have been widely used in the food and …
[HTML][HTML] Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
S Beganovic, C Rückert-Reed, H Sucipto, W Shu… - Microbial Cell …, 2023 - Springer
Background Oxytetracycline which is derived from Streptomyces rimosus, inhibits a wide
range of bacteria and is industrially important. The underlying biosynthetic processes are …
range of bacteria and is industrially important. The underlying biosynthetic processes are …
[HTML][HTML] Systems metabolic engineering of the primary and secondary metabolism of Streptomyces albidoflavus enhances production of the reverse antibiotic …
J Stegmüller, MR Estévez, W Shu, L Gläser… - Metabolic …, 2024 - Elsevier
Nybomycin is an antibiotic compound with proven activity against multi-resistant
Staphylococcus aureus, making it an interesting candidate for combating these globally …
Staphylococcus aureus, making it an interesting candidate for combating these globally …
Biocatalytic Synthesis of l‐Pipecolic Acid by a Lysine Cyclodeaminase: Batch and Flow Reactors
K Stalder, AI Benítez‐Mateos, F Paradisi - ChemCatChem, 2024 - Wiley Online Library
Abstract l‐Pipecolic Acid (l‐PA) is a valuable building block for the synthesis of
pharmaceuticals such as anesthetics and immunosuppressants. Thus, more efficient and …
pharmaceuticals such as anesthetics and immunosuppressants. Thus, more efficient and …
Strain and bioprocess development for enhanced docosahexaenoic acid production in recombinant Yarrowia lipolytica
DL Dietrich - 2023 - publikationen.sulb.uni-saarland.de
Engineered strains of the oleaginous yeast Y. lipolytica produce commercially attractive
polyunsaturated fatty acids (PUFAs). In a pioneering study, strain Af4 was shown to produce …
polyunsaturated fatty acids (PUFAs). In a pioneering study, strain Af4 was shown to produce …
Metabolic and regulatory network analysis of DHA-producing recombinant Yarrowia lipolytica
S Jovanovic Gasovic - 2023 - publikationen.sulb.uni-saarland.de
Heterologous expression of myxobacterial PKS-like PUFA cluster in recently created
recombinant Yarrowia lipolytica Af4 strain allowed formation of DHA, polyunsaturated fatty …
recombinant Yarrowia lipolytica Af4 strain allowed formation of DHA, polyunsaturated fatty …