Long non-coding RNAs in retinal ganglion cell apoptosis

N Zhang, W Cao, X He, Y Xing, N Yang - Cellular and molecular …, 2023 - Springer
Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve
transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible …

Multimerin-1 and cancer: a review

MG Posner - Bioscience reports, 2022 - portlandpress.com
Abstract Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and
coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM) …

[HTML][HTML] Translocator protein 18 kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma

Z Zeng, M You, R Rong, C Fan, M Chen, H Li, D Ji… - Redox biology, 2023 - Elsevier
Glaucoma is the leading cause of blindness worldwide. However, our insufficient
understanding of the pathogenesis of glaucoma has limited the development of effective …

Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion …

C Chen, P Fan, L Zhang, K Xue, J Hu, J Huang, W Lu… - Neuroscience, 2023 - Elsevier
Abstract Aquaporin-4 (AQP4) regulates retinal water homeostasis and participates in retinal
oedema pathophysiology. β-dystroglycan (β-DG) is responsible for AQP4 polarization and …

[HTML][HTML] Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice

P Lu, Y Shi, D Ye, X Lu, X Tang… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: Pituitary adenylate cyclase-activating polypeptide (PACAP) has shown potent
neuroprotective effects in central nervous system and retina disorders. However, whether …

Differential roles of FOXC2 in the trabecular meshwork and Schlemm's canal in glaucomatous pathology

N Ujiie, PR Norden, R Fang, L Beckmann… - Life science …, 2023 - life-science-alliance.org
Impaired development and maintenance of Schlemm's canal (SC) are associated with
perturbed aqueous humor outflow and intraocular pressure. The angiopoietin (ANGPT)/TIE2 …

MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model

C Tan, W Shi, Y Zhang, C Liu, T Hu… - Life Science …, 2023 - life-science-alliance.org
The present study focused on the effect of miR-93-5p on apoptosis of retinal neurons in
acute ocular hypertension (AOH) model by regulating PDCD4 and explored its related …

Circ_0080940 regulates miR-139-5p/CTGF pathway to promote the proliferation, migration, extracellular matrix deposition of human tenon's capsule fibroblasts

Y Wang, Y Yu, M Xu, J Zhou, G Kang, K Li - Current Eye Research, 2023 - Taylor & Francis
Abstract Purpose Circular RNA (circRNA) has been identified as an important regulator for
glaucoma progression. Our study aims to reveal the circ_0080940 roles in glaucoma …

Suprachoroidal injection of polyzwitterion hydrogel for treating glaucoma

H Hao, B He, B Yu, J Yang, X Xing, W Liu - Biomaterials Advances, 2022 - Elsevier
Glaucoma is the primary cause of irreversible blindness worldwide. The current treatments
are primarily based on drug usage or surgical operation to reduce intraocular pressure …

[HTML][HTML] Differentially expressed circRNAs in peripheral blood samples as potential biomarkers and therapeutic targets for acute angle-closure glaucoma

R Guan, S Angxiu, L Li, Z Kang, X Yan - Scientific Reports, 2023 - nature.com
Glaucoma is the leading cause of irreversible blindness globally. Circular RNAs (circRNAs)
play vital roles in various biological processes as microRNA (miRNA) sponges and, thus …