[HTML][HTML] Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Effect of coronaviruses on blood vessel permeability: potential therapeutic targets

NR Machado, KT Dias, BFS Cortes… - Therapeutic …, 2023 - journals.sagepub.com
Coronavirus-induced diseases have afflicted humanity for several decades. This scenario
was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in …

[HTML][HTML] Antimicrobial Resistance in Pseudomonas aeruginosa before and during the COVID-19 Pandemic

E Serretiello, R Manente, F Dell'Annunziata, V Folliero… - Microorganisms, 2023 - mdpi.com
Pseudomonas aeruginosa (PA) is a major Gram-negative opportunistic pathogen causing
several serious acute and chronic infections in the nosocomial and community settings. PA …

An anticomplement homogeneous polysaccharide from Hedyotis diffusa attenuates lipopolysaccharide-induced acute lung injury and inhibits neutrophil extracellular …

J Zhang, J Huo, Z Zhao, Y Lu, Z Hong, H Li, D Chen - Phytomedicine, 2022 - Elsevier
Background Owing to the involvement of the overactivated complement system in acute lung
injury (ALI) development, anticomplement components may attenuate ALI. Hedyotis diffusa …

[HTML][HTML] Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway …

OF Fagbohun, WPDW Thilakarathna, J Zhou… - Molecules, 2024 - mdpi.com
Acute lung injury (ALI) represents a life-threatening condition with high morbidity and
mortality despite modern mechanical ventilators and multiple pharmacological strategies …

Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice

K Yamamoto, H Watanabe‐Takano… - The FASEB …, 2023 - Wiley Online Library
Vascular permeability is dynamically but tightly controlled by vascular endothelial (VE)‐
cadherin‐mediated endothelial cell–cell junctions to maintain homeostasis. Thus …

[HTML][HTML] Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced respiratory failure: an exploratory proof-of-concept trial

P Chowdary, B Agarwal, MR Peralta… - Journal of Clinical …, 2023 - mdpi.com
Acute lung injury in COVID-19 results in diffuse alveolar damage with disruption of the
alveolar-capillary barrier, coagulation activation, alveolar fibrin deposition and pulmonary …

Therapeutic potential of proteases in acute lung injury and respiratory distress syndrome via TLR4/Nrf2/NF-kB signaling modulation

HM Anwar, GEM Salem, HM Abd El-Latief… - International Journal of …, 2024 - Elsevier
The COVID-19 pandemic has drawn attention to acute lung injury and respiratory distress
syndrome as major causes of death, underscoring the urgent need for effective treatments …

Does SARS-CoV-2 infect platelets?

S Subramaniam, N Mohiuddin, A Jose - Frontiers in Immunology, 2024 - frontiersin.org
COVID-19 is characterized by dysregulated thrombo-inflammatory responses and
coagulation, leading to an increased risk of mortality in affected patients (1–3). Platelets play …

[HTML][HTML] Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance …

Z Kikinis, A Castañeyra-Perdomo… - Frontiers in …, 2024 - frontiersin.org
Current views on immunity support the idea that immunity extends beyond defense functions
and is tightly intertwined with several other fields of biology such as virology, microbiology …