Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …

Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in
tumors, but its application toward dissecting mechanisms underlying immune-modulating …