[HTML][HTML] Targeting gut microbiota and metabolism as the major probiotic mechanism-An evidence-based review

T Ma, X Shen, X Shi, HA Sakandar, K Quan, Y Li… - Trends in Food Science …, 2023 - Elsevier
Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

[HTML][HTML] Gut microbial metabolites in depression: understanding the biochemical mechanisms

G Caspani, S Kennedy, JA Foster, J Swann - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Gastrointestinal and central function are intrinsically connected by the gut microbiota, an
ecosystem that has co-evolved with the host to expand its biotransformational capabilities …

Total volatile basic nitrogen and trimethylamine in muscle foods: Potential formation pathways and effects on human health

AEDA Bekhit, SG Giteru, BWB Holman… - … Reviews in Food …, 2021 - Wiley Online Library
The use of total volatile basic nitrogen (TVB‐N) as a quality parameter for fish is rapidly
growing to include other types of meat. Investigations of meat quality have recently focused …

Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?

KS Coutinho-Wolino, LFM de F. Cardozo… - European journal of …, 2021 - Springer
Abstract Background Trimethylamine N-oxide (TMAO) is a metabolite that has attracted
attention due to its positive association with several chronic non-communicable diseases …

Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice

L Qiu, X Tao, H Xiong, J Yu, H Wei - Food & function, 2018 - pubs.rsc.org
Trimethylamine N-oxide (TMAO), which is oxidized from trimethylamine (TMA) by hepatic
flavin-containing monooxygenases (FMOs), promotes the development of atherosclerosis …

The molecular and mechanistic insights based on gut–liver axis: nutritional target for non-alcoholic fatty liver disease (NAFLD) improvement

Y Ji, Y Yin, L Sun, W Zhang - International journal of molecular sciences, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is recognized as the most frequent classification of
liver disease around the globe. Along with the sequencing technologies, gut microbiota has …

Probiotics, prebiotics and synbiotics—a promising strategy in prevention and treatment of cardiovascular diseases?

B Olas - International journal of molecular sciences, 2020 - mdpi.com
Recent evidence suggests that probiotics, prebiotics and synbiotics may serve as important
dietary components in the prevention (especially) and treatment of cardiovascular diseases …

Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

C Simó, V García-Cañas - Food & function, 2020 - pubs.rsc.org
There is a growing body of clinical evidence that supports a strong association between
elevated circulating trimethylamine N-oxide (TMAO) levels with increased risk of developing …

Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose–response meta-analysis

MA Farhangi, M Vajdi, M Asghari-Jafarabadi - Nutrition journal, 2020 - Springer
Aims Several epidemiological studies have examined the association between
trimethylamine N-Oxide (TMAO) and stroke risk; however, the results are still inconclusive …