Most rare diseases still lack approved treatments despite major advances in research
providing the tools to understand their molecular basis, as well as legislation providing …

Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

Muscle damage in mdx (dystrophic) mice: The role of calcium and reactive oxygen species
Page 1 Proceedings of the Australian Physiological Society (2005) 36: 111-117 http://www.aups.org.au/Proceedings/36/111-117 …

Dystrophin deficiency causes Duchenne muscular dystrophy (DMD) in humans, an inherited
and progressive disease of striated muscle deterioration that frequently involves …

Duchenne muscular dystrophy (DMD) is a genetic disease affecting about one in every
3,500 boys. This X-linked pathology is due to the absence of dystrophin in muscle fibers …

The mdx mouse lacks dystrophin and is a model of human Duchenne muscular dystrophy.
Single mdx muscle fibres were isolated and subjected to a series of stretched (eccentric) …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of
the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining …