A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

The field of tissue engineering and regenerative medicine has made numerous advances in
recent years in the arena of fabricating multifunctional, three-dimensional (3D) tissue …

The stiffness of the extracellular matrix (ECM) plays an important role in regulating the
cellular programming. However, the mechanical characteristics of ECM affecting cell …

Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating
liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised …

Despite significant progress over the past few decades, creating a tissue-engineered
vascular graft with replicated functions of native blood vessels remains a challenge due to …

Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now
ethically accepted and is currently the only way to preserve fertility of prepubertal boys about …

Cell–cell interaction accounts for one of the most influential factors affecting the viability and
functionality of cell‐based tissue models. In this respect, various methods capable of …

In vitro human liver models are essential for drug screening, disease modeling, and cell-
based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) …

Mechanical or physical cues are associated with the growth and differentiation of embryonic
stem cells (ESCs). While the substrate stiffness or topography independently affects the …

Hepatic inflammation is a key feature of a variety of liver diseases including drug-induced
liver injury (DILI), orchestrated by the innate immune response (Kupffer cells, monocytes …