A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …
which are common and integral feature of a variety of natural products and pharmaceutical …
Involvement of cytochrome P450 in reactive oxygen species formation and cancer
EG Hrycay, SM Bandiera - Advances in Pharmacology, 2015 - Elsevier
This review examines the involvement of cytochrome P450 (CYP) enzymes in the formation
of reactive oxygen species in biological systems and discusses the possible involvement of …
of reactive oxygen species in biological systems and discusses the possible involvement of …
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer
C Chen, Y Yang, Y Guo, J He, Z Chen, S Qiu… - Cell Death & …, 2023 - nature.com
Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer
(CRC) patients. However, most CRC patients do not response well to ICB therapy …
(CRC) patients. However, most CRC patients do not response well to ICB therapy …
Cytochrome P450 pharmacogenetics and cancer
C Rodriguez-Antona, M Ingelman-Sundberg - Oncogene, 2006 - nature.com
The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …
They mediate the metabolic activation of numerous precarcinogens and participate in the …
Potential role of CYP1B1 in the development and treatment of metabolic diseases
F Li, W Zhu, FJ Gonzalez - Pharmacology & therapeutics, 2017 - Elsevier
Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development
Cytochrome P450s (CYPs) represent a large class of heme-containing enzymes that
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …
Cytochrome P450 enzymes: Novel options for cancer therapeutics
MCE McFadyen, WT Melvin, GI Murray - Molecular cancer therapeutics, 2004 - AACR
The concept of overexpression of individual forms of cytochrome P 450 enzymes in tumor
cells is now becoming well recognized. Indeed, a growing body of research highlights the …
cells is now becoming well recognized. Indeed, a growing body of research highlights the …
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis
M Kumarakulasingham, PH Rooney, SR Dundas… - Clinical Cancer …, 2005 - AACR
Abstract Purpose: The cytochromes P450 (P450) are a multigene family of enzymes with a
central role in the oxidative metabolism of a wide range of xenobiotics, including anticancer …
central role in the oxidative metabolism of a wide range of xenobiotics, including anticancer …
Cytochrome P450 1B1 Is Overexpressed and Regulated by Hypomethylation in Prostate Cancer
T Tokizane, H Shiina, M Igawa, H Enokida… - Clinical cancer …, 2005 - AACR
Abstract Purpose: Cytochrome P 450 1B1 (CYP1B1), a dioxin inducible member of the CYP
supergene family, is overexpressed in various human malignancies including prostate …
supergene family, is overexpressed in various human malignancies including prostate …
Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery
Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs,
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …