Antimicrobial peptides immune modulation role in intracellular bacterial infection

DI Duarte-Mata, MC Salinas-Carmona - Frontiers in Immunology, 2023 - frontiersin.org
Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes
infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to …

Granulocytes subsets and their divergent functions in host resistance to Mycobacterium tuberculosis—a 'tipping-point'model of disease exacerbation

KD Mayer-Barber - Current Opinion in Immunology, 2023 - Elsevier
Granulocytes are innate immune effector cells with essential functions in host resistance to
bacterial infections. I will discuss emerging evidence that during Mycobacterium tuberculosis …

Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases

A Selvapandiyan, N Puri, P Kumar… - FEMS Microbiology …, 2023 - academic.oup.com
The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …

Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection

K Dijkman, N Aguilo, C Boot, SO Hofman… - Cell Reports …, 2021 - cell.com
To fight tuberculosis, better vaccination strategies are needed. Live attenuated
Mycobacterium tuberculosis-derived vaccine, MTBVAC, is a promising candidate in the …

Mycobacterium tuberculosis PE/PPE proteins enhance the production of reactive oxygen species and formation of neutrophil extracellular traps

M García-Bengoa, M Meurer, M Stehr… - Frontiers in …, 2023 - frontiersin.org
Introduction Neutrophil granulocytes predominate in the lungs of patients infected with
Mycobacterium tuberculosis (Mtb) in earlier stages of the disease. During infection …

[HTML][HTML] The immune response in tubercular uveitis and its implications for treatment: From anti-tubercular treatment to host-directed therapies

I Putera, B Schrijver, JCEM Ten Berge, V Gupta… - Progress in Retinal and …, 2023 - Elsevier
Tubercular uveitis (TB-uveitis) remains a conundrum in the uveitis field, which is mainly
related to the diverse clinical phenotypes of TB-uveitis. Moreover, it remains difficult to …

Platelet activation and the immune response to tuberculosis

DE Kirwan, DLW Chong, JS Friedland - Frontiers in Immunology, 2021 - frontiersin.org
In 2019 10 million people developed symptomatic tuberculosis (TB) disease and 1.2 million
died. In active TB the inflammatory response causes tissue destruction, which leads to both …

Tweaking host immune responses for novel therapeutic approaches against Mycobacterium tuberculosis

A Roy, PK Agnivesh, S Sau, S Kumar, NP Kalia - Drug Discovery Today, 2023 - Elsevier
In TB, combat between the human host and Mycobacterium tuberculosis involves intricate
interactions with immune cells. M. tuberculosis has evolved a complex evasion system to …

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

TG Kang, KW Kwon, K Kim, I Lee, MJ Kim, SJ Ha… - Nature …, 2022 - nature.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is often exacerbated upon
coinfection, but the underlying immunological mechanisms remain unclear. Here, to …

Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection

AA Starshinova, I Kudryavtsev, A Malkova… - International Journal of …, 2022 - mdpi.com
Tuberculosis is still an important medical and social problem. In recent years, great strides
have been made in the fight against M. tuberculosis, especially in the Russian Federation …