[HTML][HTML] A roadmap for metagenomic enzyme discovery
SL Robinson, J Piel, S Sunagawa - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
Cytochrome P450 enzymes in fungal natural product biosynthesis
X Zhang, J Guo, F Cheng, S Li - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …
terpenoids and their hybrids contribute significantly to the chemical space of total natural …
Enzymatic nitrogen insertion into unactivated C–H bonds
Selective functionalization of aliphatic C–H bonds, ubiquitous in molecular structures, could
allow ready access to diverse chemical products. While enzymatic oxygenation of C–H …
allow ready access to diverse chemical products. While enzymatic oxygenation of C–H …
Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces
S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …
Biosynthesis of cyclopropane in natural products
Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …
pharmaceutical chemistry, and chemical biology because of its unique structural and …
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …
the structural diversity found in the superfamily of terpenoid natural products. These elegant …
Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C− N Linkage Formed by CYP450 Catalysis
Abstract Cihunamides A–D (1–4), novel antibacterial RiPPs, were isolated from volcanic‐
island‐derived Streptomyces sp. The structures of 1–4 were elucidated by 1H, 13C, and 15N …
island‐derived Streptomyces sp. The structures of 1–4 were elucidated by 1H, 13C, and 15N …
[HTML][HTML] North Sea spring bloom-associated Gammaproteobacteria fill diverse heterotrophic niches
B Francis, T Urich, A Mikolasch, H Teeling… - Environmental …, 2021 - Springer
Background The planktonic bacterial community associated with spring phytoplankton
blooms in the North Sea is responsible for a large amount of carbon turnover in an …
blooms in the North Sea is responsible for a large amount of carbon turnover in an …
Outer membrane vesicles catabolize lignin-derived aromatic compounds in Pseudomonas putida KT2440
Lignin is an abundant and recalcitrant component of plant cell walls. While lignin
degradation in nature is typically attributed to fungi, growing evidence suggests that bacteria …
degradation in nature is typically attributed to fungi, growing evidence suggests that bacteria …