[HTML][HTML] A roadmap for metagenomic enzyme discovery

SL Robinson, J Piel, S Sunagawa - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

Cytochrome P450 enzymes in fungal natural product biosynthesis

X Zhang, J Guo, F Cheng, S Li - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

Enzymatic nitrogen insertion into unactivated C–H bonds

SV Athavale, S Gao, A Das, SC Mallojjala… - Journal of the …, 2022 - ACS Publications
Selective functionalization of aliphatic C–H bonds, ubiquitous in molecular structures, could
allow ready access to diverse chemical products. While enzymatic oxygenation of C–H …

Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases

H Nam, JS An, J Lee, Y Yun, H Lee… - Journal of the …, 2023 - ACS Publications
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces

S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Biosynthesis of cyclopropane in natural products

S Ma, D Mandalapu, S Wang, Q Zhang - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

JD Rudolf, CY Chang - Natural product reports, 2020 - pubs.rsc.org
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C− N Linkage Formed by CYP450 Catalysis

JS An, H Lee, H Kim, S Woo, H Nam, J Lee… - Angewandte …, 2023 - Wiley Online Library
Abstract Cihunamides A–D (1–4), novel antibacterial RiPPs, were isolated from volcanic‐
island‐derived Streptomyces sp. The structures of 1–4 were elucidated by 1H, 13C, and 15N …

[HTML][HTML] North Sea spring bloom-associated Gammaproteobacteria fill diverse heterotrophic niches

B Francis, T Urich, A Mikolasch, H Teeling… - Environmental …, 2021 - Springer
Background The planktonic bacterial community associated with spring phytoplankton
blooms in the North Sea is responsible for a large amount of carbon turnover in an …

Outer membrane vesicles catabolize lignin-derived aromatic compounds in Pseudomonas putida KT2440

D Salvachúa, AZ Werner, I Pardo… - Proceedings of the …, 2020 - National Acad Sciences
Lignin is an abundant and recalcitrant component of plant cell walls. While lignin
degradation in nature is typically attributed to fungi, growing evidence suggests that bacteria …