Adaptive proton therapy
Radiation therapy treatments are typically planned based on a single image set, assuming
that the patient's anatomy and its position relative to the delivery system remains constant …
that the patient's anatomy and its position relative to the delivery system remains constant …
[HTML][HTML] Roadmap: helium ion therapy
Helium ion beam therapy for the treatment of cancer was one of several developed and
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …
[HTML][HTML] Reduction of clinical safety margins in proton therapy enabled by the clinical implementation of dual-energy CT for direct stopping-power prediction
Purpose To quantifiy the range uncertainty in proton treatment planning using dual-energy
computed tomography (DECT) for a direct stopping-power prediction (DirectSPR) algorithm …
computed tomography (DECT) for a direct stopping-power prediction (DirectSPR) algorithm …
[HTML][HTML] Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy?
BS Sørensen, J Pawelke, J Bauer, NG Burnet… - Radiotherapy and …, 2021 - Elsevier
Clinical treatment with protons uses the concept of relative biological effectiveness (RBE) to
convert the absorbed dose into an RBE-weighted dose that equals the dose for radiotherapy …
convert the absorbed dose into an RBE-weighted dose that equals the dose for radiotherapy …
[HTML][HTML] Considerations for upright particle therapy patient positioning and associated image guidance
Particle therapy is a rapidly growing field in cancer therapy. Worldwide, over 100 centers are
in operation, and more are currently in construction phase. The interest in particle therapy is …
in operation, and more are currently in construction phase. The interest in particle therapy is …
[HTML][HTML] Dual-and multi-energy CT for particle stopping-power estimation: current state, challenges and potential
Range uncertainty has been a key factor preventing particle radiotherapy from reaching its
full physical potential. One of the main contributing sources is the uncertainty in estimating …
full physical potential. One of the main contributing sources is the uncertainty in estimating …
[HTML][HTML] Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy
Background and purpose Studies have shown large variations in stopping-power ratio
(SPR) prediction from computed tomography (CT) across European proton centres. To …
(SPR) prediction from computed tomography (CT) across European proton centres. To …
[HTML][HTML] A survey of practice patterns for adaptive particle therapy for interfractional changes
Background and purpose Anatomical changes may compromise the planned target
coverage and organs-at-risk dose in particle therapy. This study reports on the practice …
coverage and organs-at-risk dose in particle therapy. This study reports on the practice …
[HTML][HTML] First-in-human validation of CT-based proton range prediction using prompt gamma imaging in prostate cancer treatments
J Berthold, C Khamfongkhruea, J Petzoldt… - International Journal of …, 2021 - Elsevier
Purpose Uncertainty in computed tomography (CT)-based range prediction substantially
impairs the accuracy of proton therapy. Direct determination of the stopping-power ratio …
impairs the accuracy of proton therapy. Direct determination of the stopping-power ratio …
[HTML][HTML] The current status of FLASH particle therapy: a systematic review
Particle therapies are becoming increasingly available clinically due to their beneficial
energy deposition profile, sparing healthy tissues. This may be further promoted with ultra …
energy deposition profile, sparing healthy tissues. This may be further promoted with ultra …