Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery
from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or …

Nociceptive signals originating in the periphery are conveyed to the brain through specific
afferent and ascending pathways. The spino-(trigemino-) parabrachio-amygdaloid pathway …

Pyramidal neuron (Pyn) hyperactivity in the anterior cingulate cortex (ACC) is involved in the
modulation of pain. Previous studies indicate that the activation of α2 adrenoceptors (α2 …

Acute pain that persists for a few days is associated with a reduction in patients' quality of
life. Orofacial persistent pain promotes psychological disorders such as anxiety, impairs …

Aniridia is a panocular disease causing progressive severe visual impairment and blindness
due to PAX-6 haploinsufficiency. One of the most disabling ocular symptoms is aniridia …

Critical for organismal survival, pain evokes strong physiological and behavioral responses
in various sentient species. Clinical and preclinical (animal) studies markedly increase our …

The etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is
multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor …

Ketamine is known for its antinociceptive effect and is also used for treatment‐resistant
depression. However, the efficacy and safety of (2R, 6R)‐hydroxynorketamine (HNK), a …

Background Insufficient sleep alters the body's physiological functions. This study
investigated whether oxidative stress (OS) in the thalamus was correlated with the pain …

Abstract Nav1. 7, one of tetrodotoxin-sensitive voltage-gated sodium channels, mainly
expressed in the small diameter dorsal root ganglion (DRG) neurons. The expression and …