[HTML][HTML] Antitumor activity of kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice

CR Figueiredo, AL Matsuo, MH Massaoka… - Advanced …, 2014 - ncbi.nlm.nih.gov
Purpose: The antitumor activity of Kielmeyera coriacea (Clusiaceae), a medicinal plant used
in the treatment of parasitic, as well as fungal and bacterial infections by the Brazilian …

δ-Tocotrienol suppresses tumorigenesis by inducing apoptosis and blocking the COX-2/PGE2 pathway that stimulates tumor–stromal interactions in colon cancer

S Wada, Y Naito, Y Matsushita, M Nouchi… - Journal of functional …, 2017 - Elsevier
Anticancer effects of δ-tocotrienol have been reported for several types of cancer, but have
not been fully elucidated in colorectal cancer. We investigated the anti-proliferative effect of …

Chemoprevention of azoxymethane-induced colon carcinogenesis by delta-tocotrienol

K Husain, A Zhang, S Shivers, A Davis-Yadley… - Cancer Prevention …, 2019 - AACR
This study evaluated the preclinical activity of δ-tocotrienol (DT3), a bioactive form of vitamin
E, in the inhibition of colorectal cancer growth and development in vitro and in vivo. DT3 is …

[HTML][HTML] Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis

K Husain, D Coppola, CS Yang, MP Malafa - Scientific reports, 2021 - nature.com
The activation and growth of tumour-initiating cells with stem-like properties in distant organs
characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon …

Antioxidant and cytotoxicity activities of δ-tocotrienol from the seeds of Allophylus africanus

JF Zeutsop, JN Zébazé, RN Nono, M Frese… - Natural Product …, 2021 - Taylor & Francis
Chemical investigation of Allophylus africanus P. Beauv fruits led to the isolation of a new δ-
tocotrienol, 3 α-hydroxy-δ-tocotrienol (1) together with eight known compounds (2-9) …

Antioxidant compounds of Kielmeyera coriacea Mart. with α-amylase, lipase and advanced glycation end-product inhibitory activities

AB Justino, EC Santana, RR Franco, JS Queiroz… - … of Pharmaceutical and …, 2021 - Elsevier
Chronic hyperglycemia and hyperlipidemia are associated with excessive formation of
reactive oxygen species and advanced glycation end-products. The present study aimed to …

Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia paucinervis

X Tan, F Zhong, H Teng, Q Li, Y Li, Z Mei, Y Chen… - Fitoterapia, 2020 - Elsevier
Three undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) and three
tocotrienols derivatives, named as paucinochymol AF (1–3 and 10–12), together with six …

A new tocotrienol from the roots and branches of Allophylus cobbe (L.) Raeusch (Sapindaceae)

W Sangsopha, FT Schevenels, R Lekphrom… - Natural product …, 2020 - Taylor & Francis
Abstract A new tocotrienol, 5-hydroxy-8-methyltocotrienol (1) was isolated from the roots and
branches of A. cobbe (L.) Raeusch, together with seventeen known compounds (2–18) …

Update on the anti-cancer potency of tocotrienols and α-tocopheryl polyethylene glycol 1000 succinate on leukemic cell lines

C Constantinou, C Charalambous, D Kanakis… - Nutrition and …, 2021 - Taylor & Francis
The natural isoforms of vitamin E γ-tocotrienol (γ-ΤΤ) and δ-tocotrienol (δ-ΤΤ) and the
synthetic derivative α-tocopheryl polyethylene glycol 1000 succinate (TPGS) have promising …

Garcinoic acid: a promising bioactive natural product for better understanding the physiological functions of tocopherol metabolites

S Kluge, M Schubert, L Schmölz, M Birringer… - Studies in natural …, 2016 - Elsevier
Garcinia kola is traditionally used in African medicine by people who believe that it has
purgative, antiparasitic, and antimicrobial properties. The seeds are used for treating …