Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth and
progression. The first biochemical descriptions of the altered metabolic nature of solid …

The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine
kinase, which has a central function in integrating growth signals and orchestrating their …

Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising
fibroblasts, cells of the immune system, and endothelial cells, besides various soluble …

Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading
cause of cancer death among men in Western countries. Current screening techniques are …

The analysis of cancer metabolome has shown that proliferating tumor cells require a large
quantities of different nutrients in order to support their high rate of proliferation. In this study …

Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH
can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on …