Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

Islet transplantation is an established therapy for diabetes. We have previously shown that
rat pancreata can be created from rat pluripotent stem cells (PSCs) in mice through …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …

BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …

Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …