Biomaterials and advanced technologies for hemostatic management of bleeding
DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …
associated, or drug‐induced blood disorders can cause significant morbidities and …
Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Turbulence activates platelet biogenesis to enable clinical scale ex vivo production
Y Ito, S Nakamura, N Sugimoto, T Shigemori, Y Kato… - Cell, 2018 - cell.com
The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …
expected to compensate donor-dependent transfusion systems. However, manufacturing the …
Stem cells in the treatment of disease
HM Blau, GQ Daley - New England Journal of Medicine, 2019 - Mass Medical Soc
Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …
Interspecies organogenesis generates autologous functional islets
T Yamaguchi, H Sato, M Kato-Itoh, T Goto, H Hara… - Nature, 2017 - nature.com
Islet transplantation is an established therapy for diabetes. We have previously shown that
rat pancreata can be created from rat pluripotent stem cells (PSCs) in mice through …
rat pancreata can be created from rat pluripotent stem cells (PSCs) in mice through …
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …
iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study
N Sugimoto, J Kanda, S Nakamura… - Blood, The Journal …, 2022 - ashpublications.org
Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …
Use of differentiated pluripotent stem cells in replacement therapy for treating disease
BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …
Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …
Scalable generation of universal platelets from human induced pluripotent stem cells
Q Feng, N Shabrani, JN Thon, H Huo, A Thiel… - Stem cell reports, 2014 - cell.com
Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …
the production of transfusable platelets. Here, we describe a method to generate …