Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging
JY Akakpo, H Olivos, B Shrestha, A Midey… - Toxicological …, 2024 - academic.oup.com
Acute kidney injury (AKI) is a common complication in acetaminophen (APAP) overdose
patients and can negatively impact prognosis. Unfortunately, N-acetylcysteine, which is the …
patients and can negatively impact prognosis. Unfortunately, N-acetylcysteine, which is the …
CLEC-1 Restrains Acute Inflammatory Response and Recruitment of Neutrophils following Tissue Injury
C Ligeron, J Saenz, B Evrard, M Drouin… - The Journal of …, 2024 - journals.aai.org
The inflammatory response is a key mechanism for the elimination of injurious agents but
must be tightly controlled to prevent additional tissue damage and progression to persistent …
must be tightly controlled to prevent additional tissue damage and progression to persistent …
[HTML][HTML] Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure
K Roth, J Strickland, A Pant, R Freeborn… - Frontiers in …, 2023 - frontiersin.org
Introduction Systemic levels of the anti-inflammatory cytokine interleukin 10 (IL-10) are
highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with the poorest …
highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with the poorest …
[HTML][HTML] The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying …
DS Umbaugh, NT Nguyen, SH Smith… - Toxicology, 2024 - Elsevier
Fifty percent of all acute liver failure (ALF) cases in the United States are due to
acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as …
acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as …
Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
AJ Layman, SM Alsbrook, IK Koturbash… - Journal of Dietary …, 2024 - Taylor & Francis
Acetaminophen (APAP) overdose is one of the most common causes of acute liver injury.
The current standard-of-care treatment for APAP hepatotoxicity, N-acetyl-l-cysteine, is highly …
The current standard-of-care treatment for APAP hepatotoxicity, N-acetyl-l-cysteine, is highly …
[HTML][HTML] The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review
Acetaminophen (APAP) is a widely used drug, but overdose can cause severe acute liver
injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly …
injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly …
[HTML][HTML] Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies
A Schulte, DJ Groeneveld, Z Wei, B Hazel… - Research and Practice …, 2024 - Elsevier
Background Acetaminophen (APAP) overdose is a leading cause of drug-induced acute
liver failure (ALF). Neutrophil activation has been associated with poor outcomes in patients …
liver failure (ALF). Neutrophil activation has been associated with poor outcomes in patients …
OPEN ACCESS EDITED BY
B Ravindran, S Panda, EN Harris… - Myeloid cells in health …, 2024 - books.google.com
The liver plays a crucial role in the immune system by serving as a vital organ responsible
for removing toxins, producing immune proteins, and maintaining metabolic homeostasis …
for removing toxins, producing immune proteins, and maintaining metabolic homeostasis …
[PDF][PDF] Human Health Effects of Chronic Cadmium TS Exposure ey
Cadmium (Cd) is a hazardous unnecessary transition metal that is harmful to people and
animals. Cadmium is naturally prevalent in the environment and is frequently obtained from …
animals. Cadmium is naturally prevalent in the environment and is frequently obtained from …