The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …

Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Aims Nocturnal acid breakthrough has been considered an unmet need of proton‐pump
inhibitors. Tegoprazan, a novel potassium‐competitive acid blocker, is expected to show …

Nowadays, many relevant drug–gene associations have been discovered, but
pharmacogenomics (PGx)-guided treatment needs to be cost-effective as well as clinically …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used
globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary …

Codeine is used to relieve mild to moderately severe pain, and it belongs to the drug class of
opioid analgesics. Codeine has also been prescribed to prevent coughing, though the …

Background Cardiovascular diseases and especially Acute Coronary Syndrome (ACS)
constitute a major health issue impacting millions of patients worldwide. Being a leading …

The search for genetic risk factors underlying the presumed heritability of all human
behavior has unfolded in two phases. The first phase, characterized by candidate-gene …