The thiopurine drugs—azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine—are
widely used to treat malignancies, rheumatic diseases, dermatologic conditions …

Importance of the field: The Glutathione S-transferases (GSTs) have advanced beyond the
classic view of their role in metabolism and are encouraging scientists to assess new …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

The thiopurine drugs azathioprine and 6‐mercaptopurine (6‐MP) are well‐established in the
treatment of inflammatory bowel disease (IBD). However, there is a wide inter‐and intra …

For several decades, dermatologists have utilized azathioprine to treat numerous
debilitating skin diseases. This synthetic purine analog is derived from 6-mercaptopurine. It …

Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …

Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background Thiopurines represent an
effective and widely prescribed therapy in inflammatory bowel disease (IBD). Concerns …

Purpose: P‐glycoprotein (P‐gp) has been implicated in the causation of refractory epilepsy.
The expression and efflux efficiency of P‐gp is influenced by a polymorphism (C3435T) in …

Abstract Background The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the
metabolism of many drugs and xenobiotics. As it represents a likely target of population …

There is wide variability in the response of individuals to standard doses of drug therapy.
This is an important problem in clinical practice, where it can lead to therapeutic failures or …