Optical properties of tissue can reveal much more diagnostically relevant information than
has as yet been capitalised on in patients' health care. Only very few optical methods, such …

The essential feature of the confocal laser scanning microscope (cLSM) is the generation of
optical sections by the removal of out-of-focus light. About ten years ago, structured …

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric
technique that is particularly attractive for biomedical imaging. Here we show that combining …

It was not until the 1930s that measurement of the fluorescence lifetime (τ f) and the
confirmation of theory on this phenomenon became possible (Pringsheim, 1961). Before that …

We have developed a photon-counting High-temporal and High-spatial resolution, High-
throughput 3-Dimensional detector (H33D) for biological imaging of fluorescent samples …

Systems and methods for increasing the RF power switched into a resonant load by
achieving voltage multiplication by means of coupled inductors are provided herein. In one …

This invention relates to a pulse generator circuit for delivering a short high current pulse to
a load. This pulse generator comprises a junction recovery diode, a switch, a first resonant …

In this chapter, the concept of fluorescence lifetime and its utility in quantitative live cell
imaging will be introduced, along with methods to record and analyze FLIM data. Relevant …

We report a wide-field fluorescence lifetime imaging (FLIM) system that uses a blue
picosecond pulsed diode laser as the excitation source. This represents a significant …

Fluorescent lifetime imaging microscopy is a powerful tool to enhance the contrast in images
of biological samples and to investigate the local environment of a fluorochrome. FLIM …