Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Background Cancer is one of the greatest public health challenges worldwide, and we still
lack complementary approaches to significantly enhance the efficacy of standard anticancer …

Background: The objective of this open-label pilot study was to investigate the efficacy of a
very-low-carbohydrate ketogenic diet (VLCKD), known as Nic's Ketogenic Diet, for 140 days …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

The striking and unexpected relative risk reductions in cardiovascular (CV) mortality (38%),
hospitalization for heart failure (35%), and death from any cause (32%) observed in the …

How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the
tumor microenvironment (TME) and to what degree this affects their ability to combat tumor …

Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …

Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering
oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly …

Evidence has emerged that the failing heart increases utilization of ketone bodies. We
sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing …

Background—Significant evidence indicates that the failing heart is energy starved. During
the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel …